T cell tyrosine phosphorylation response to transient redox stress

Protein tyrosine phosphorylation in T cell signaling.

This review discusses in considerable detail the tyrosine phosphorylation events that couple the T cell antigen receptor to downstream signaling pathways. First, the protein kinases that catalyze these tyrosine phosphorylation are introduced, then the phosphatases that mediate removal of phosphate from tyrosine residues. Next, we discuss the molecular clock work by which these enzymes initiated...

Protein Tyrosine Phosphatases Isolated T Cell Membrane by Inhibition of Regulation of Tyrosine Phosphorylation in

Histidine and tyrosine phosphorylation in pea mitochondria: evidence for protein phosphorylation in respiratory redox signalling.

A 37 kDa protein in pea mitochondria was found to contain phosphorylated residues. Phosphorylation was acid-labile but stable in alkali solution, a unique property of phosphorylation on histidine, indicating that a signal transduction pathway with homology to bacterial two-component systems might exist in plant mitochondria. We also describe the first example of tyrosine phosphorylation in plan...

Response Multilayered Control of T Cell Receptor Phosphorylation

2009); the catalytic activities of PTPs have been estimated to be 10to 1000-fold higher than that of tyrosine kinases (discussedby Fischer et al., 1991). Another contributing factor is the activity of inhibitory kinases such as Csk, which also constrain T cell activation (Schoenborn et al., 2009). Progress in understanding TCR triggering will require the teasing apart of these and other competi...

Decreased T Cell Response to Mitogen and Increased Anti-cytoplasmic Antibody in Drug-Free Schizophrenic Patients

Background: Apart from genetic and environmental factors, activation of autoreactive mechanisms has been proposed to play a role in the pathogenesis of schizophrenia. In re-cent years, considerable work has been carried out to understand the role and contribution of the immune system in this disease. Objective: To investigate the T cell response to phytohaemagglutinin (PHA) and determine the se...